Hypofractionated radiation therapy has proven effective on locoregional control and\ntolerance in the adjuvant treatment of breast cancer. The aim of this study is to\ncompare the results of hypofractionated radiation therapy versus conventional radiation\ntherapy in terms of local control and tolerance. It was a retrospective study of\npatients observations collected from January 2007 to December 2008 in Department\nof Radiation Therapy in Institut National dâ��Oncologie de Rabat. The treatment results\nwere evaluated by the rate of locoregional recurrence, distant recurrence and\nresearch of late toxicities. Radiotherapy was delivered using the same technique in\nboth groups, by gamma photons of cobalt 60 with an energy of 1.25 MeV. They were\n2 groups: the first group treated with standard dose rate and the second group\ntreated by hypofractionated radiation therapy. The mean age of the patients was 42.8\n�± 6.9 years old in the standard group and 43.22 �± 7.2 years old in the hypofractionation\ngroup. We noted a predominance of infiltrating ductal carcinoma. The majority\nof patients were pT2, pN0 and pN1. The majority of patients had radical surgery and\nchemotherapy with anthracyclines in both groups. We noted a statistically significant\ndifference in the irradiation of chest wall between the standard (89.2%) and hypofractionated\ngroup (70.3%), with p = 0.043. The median duration of radiation therapy\nwas statistically different in both groups: 39 days in the standard and 23 days in\nthe hypofractionated group (p < 0.001). The local recurrences were statistically identical\nto 12 and 24 months (p = 0.999). Concerning toxicities, the frequency of adverse\nevent was similar in both groups. Hypofractionated radiation therapy with a total\ndose of 42 Gy at 2.8 Gy per fraction in 5 fractions weekly is comparable to standard\nradiotherapy in terms of local control and tolerance and is therefore a very good alternative\nto standard treatment.
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